Benjamin Shapiro, Ph.D.
Professor, Fischell Department of Bioengineering, University of Maryland, College Park, MD, U.S.A.
Results and Challenges in Magnetically Targeting Therapy to Disease Targets
Dr. Benjamin Shapiro’s group is developing magnet systems to direct and focus therapy to disease targets in the body. The goal is to design, construct, test and deliver to patients advanced magnet systems that can put the right drug or gene in the right place in the body. He will discuss how dynamic control of magnets (and exploitation of nanoparticle physics) can be used to focus therapy to deep targets between magnets, how magnet design can be used to deliver therapy to ear and eye targets via a ‘magnetic syringe’, as well as recent advances in ultra-fast MR imaging to enable real-time image-guided control of therapy distribution in the human body.
Tomasz Dietl, Ph.D.
Professor, Laboratory of Cryogenic and Spintronic Research, Institute of Physics, Polish Academy of Sciences, Warszawa, POLAND; P.I., Advanced Institute for Materials Research, Tohoku University, Sendai, JAPAN
Nanospintronics Meets Magnetic Nanoparticles
The minimum feature size of today’s spintronic devices, obtained by top-down methods, reaches 11 nm. At the same time, spinodal nanotechnology, a novel self-assembling method, allows one to obtain arrays of magnetic nanoparticles and nanocolumns embedded in functional semiconductors. Dr. Tomasz Dietl, a spintronic expert, will review the recent breakthrough progress in random access and logic-in magnetic memories. He will then discuss the flow of ideas between nanospintronic and nanoparticle fields, including the questions of surface/interfacial magnetism, magnetic cross-talking, thermal stability, magnetization reversal modes (nucleation vs. single-domain like), and cross-over between semiclassical and quantum spin dynamics.
Maxime Dahan, Ph.D.
Directeur de l'unité Physico-Chimie, Institut Curie, CNRS UMR 168 et UPMC, Paris, France
Magnetogenetic Control of Cell Signaling
Remote actuation of cellular processes is an important challenge in cell biology. Here, Dr. Dahan will show how functionalized magnetic nanoparticles can be used to control signalling processes in the cytoplasm of living cells.
Hakho Lee, Ph.D.
Associate Professor, Center for Systems Biology
Massachusetts General Hospital / Harvard Medical School, Boston, MA, U.S.A.
Magnetic Sensors for Clinical Diagnostics: from Nanoscale Vesicles to Cancer Cells
Magnetic detection can be highly selective even in complex biological media because of the inherently negligible magnetic background of biological objects. As such, the need for extensive sample purification is obviated, which not only minimizes sample loss, but also simplifies assay procedure. In this presentation, Dr. Lee will review various magnetic sensors that his group has developed for clinical applications. Specific focus will be on cancer detection.
Jerome Lewis, Ph.D.
Advanced Magnetics, Boston, MA, U.S.A.
Superparamagnetic Iron Oxides, from the Lab to Approval
The path from basic research through comprehensive medicinal chemistry, preclinical, clinical studies, and final approval. Dr. Lewis will discuss all this on real life examples of magnetic particle products. He will especially discuss the regulatory obstacles and how to overcome them. Examples of successes and failures will be given by one of the pioneers in this area.
Ryan Gilbert, Ph.D.
Associate Professor, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, U.S.A.
Combinatorial Biomaterial Approaches Using Iron Oxide
Nanoparticles to Direct Axonal Regeneration Following Spinal Cord Injury
Following spinal cord injury, white matter tracts are severed leading to loss of function below the level of injury. The goal of this talk is to discuss our laboratory's current biomaterial approaches for fostering spinal cord regeneration with special emphasis on the role of iron oxide nanoparticles in such approaches.